THE 2-MINUTE RULE FOR ONOLIDINE

There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to lower afferent pain transmission and produce analgesia. As a result, medicines like clonidine that focus on alpha-2 receptors can influence the transmission of suffering.Clonidine treats large hyp